C. difficile and antibiotics not necessarily linked

October 7, 2008

The latest study by Dr. Sandra Dial from the Research Institute of the MUHC, McGill University, and Attending Staff in the Intensive Care Unit at the Jewish General Hospital, questions the assumption held by a vast majority of medical professionals that Clostridium difficile (C.difficile) infections are essentially always preceded by antibiotic use. This finding could have a major impact on how patients with diarrhea are evaluated upon their admission to the hospital. This study will appear in the October 6 issue of the Canadian Medical Association Journal (CMAJ).

The researchers analyzed only C. difficile infections acquired outside the hospital by patients aged 65 or older, and serious enough to require a hospitalization. Patients with hospital-acquired C.difficile infections were excluded because of the increased risk of infection and antibiotic use in the hospital environment.

Their results show that 53% of the patients studied had not been exposed to antibiotics during the 45 days preceding their C.difficile-related hospitalisation. A rate that decreased to 46% when the pre-hospitalization timeframe analysed was extended to 90 days. "These figures show that approximately 50% of community-acquired C. difficile infections are not related to antibiotic use," explained Dr. Dial. "While antibiotic use indeed plays an important role, other factors are likely to also be important. But we still need to determine what these other risk factors are."

More precisely, this study demonstrates that the highest risk of C. difficile infection due to antibiotic use occurs during the 30 days following treatment. According to Dr. Dial, "Beyond the 45-day period following treatment, the risk declines significantly".

"We believe that all patients suffering from diarrhea, particularly if severe enough to require a hospital visit, should be tested for C.difficile at their arrival in the hospital. Right now, testing is mainly done on patients who have taken antibiotics, which probably means that not everyone is receiving a correct diagnosis," warned Dr. Dial.

Source: McGill University Health Centre

Explore further: Microbe artwork shows the limits of antibiotics

Related Stories

Microbe artwork shows the limits of antibiotics

September 28, 2015

An Oxford University research fellow has been creating art using bacteria found in the human gut and harvested from faecal samples. But while the striking colours and plant like shapes may look beautiful, they also illustrate ...

Doctors identify patients at high risk of C. difficile

April 1, 2009

Doctors have developed and validated a clinical prediction rule for recurrent Clostridium difficile (C. difficile) infection that was simple, reliable and accurate, and can be used to identify high-risk patients most likely ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.