Taurine is a potent antioxidant with hepatoprotective effects. Organelle based changes in hepatocytes after taurine treatment in experimental liver fibrosis were searched systematically and organelle injury scores decreased were found to decrease significantly. Moreover, ultrastructural and histopathological scores in both groups were in strong correlation.
A research article to be published on August 21, 2008 in the World Journal of Gastroenterology addresses this question. The research team led by Mehmet Refik Mas from Gulhane School of Medicine in Turkey added a new information to their ongoing research works. Based on the fact that tissue health is directly related to functional recovery of the parenchyma cells during injury, the authors addressed the changes in major organelles in hepatocytes after administration of a hepatoprotective agent.
They not only demonstrated ultrastructural recovery with Taurine, but also reported that electron microscopy findings are reflected truly with light microscopy with the currently used scoring systems.
The results are to be helpful in future research in liver fibrosis.
The study is experimental; therefore, clinical confirmation is necessary. However, it can be postulated that similar changes occur in human hepatocytes in human chronic liver diseases if recovery can be attained.
Gulhane School of Medicine is a part of a large medical academy that was founded more than a century ago as a health staff source for the Turkish army. The academy currently supports not only institutional research projects but also keeps national and international scientific collaborations.
Source: World Journal of Gastroenterology