Gastric cancer with 3 pathological features

September 18, 2008

Primary carcinoma of the stomach is almost always adenocarcinoma or signet ring cell carcinoma and there are few reports of choriocarcinoma or neuroendocrine cell carcinoma. We report a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma. This is the first reported case of gastric cancer with these three pathological features.

A case article to be published on 28 May 2008 in the World Journal of Gastroenterology addresses this report. The research team led by Prof. Yasumitsu Hirano from Kanazawa University Graduate school of Medical Science described a patient with adenocarcinoma of the stomach combined with choriocarcinoma and neuroendocrine cell carcinoma.

They reported that a 85-year-old man presented to the hospital because of appetite loss. Gastric fiberscopy revealed a large tumor occupying the cardial region and anterior wall of the gastric body. The patient underwent total gastrectomy with lymphnode dissection and partial resection of the liver. In the gastric tumor, choriocarcinoma, small cell carcinoma and tubular adenocarcinoma were existed. The choriocarcinomatous foci contained cells positive for beta-subunit of human chorionic gonadotropin (B-hCG) and human placental lactogen mainly in syncytiotrophoblastic cells. The small cell carcinomatous foci contained cells positive for synaptophysin, neuron-specific enolase (NSE), and chromogranin A.

The prognosis for gastric adenocarcinoma with choriocarcinoma and neuroendocrine cell carcinoma is exceedingly poor. This patient died about 2 month after the first complaint from hepatic failure. This is the first reported case of gastric cancer with these three pathological features.

Source: World Journal of Gastroenterology

Explore further: Three esophageal cancer cell lines commonly used in research prove to be from other cancers

Related Stories

Yes-associated protein: Early diagnosis of gastric carcinoma

September 17, 2009

Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. In recent years, some investigators have found YAP to be overexpressed and highly activated in hepatic cancers and mammary ...

ASGE issues guideline on ethnic issues in endoscopy

June 3, 2010

The American Society for Gastrointestinal Endoscopy (ASGE) has issued guidelines addressing ethnicity, gastrointestinal diseases and endoscopic procedures. The guideline suggests that colorectal cancer screening should begin ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Cow embryos reveal new type of chromosome chimera

May 27, 2016

I've often wondered what happens between the time an egg is fertilized and the time the ball of cells that it becomes nestles into the uterine lining. It's a period that we know very little about, a black box of developmental ...

Shaving time to test antidotes for nerve agents

February 29, 2016

Imagine you wanted to know how much energy it took to bike up a mountain, but couldn't finish the ride to the peak yourself. So, to get the total energy required, you and a team of friends strap energy meters to your bikes ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.