St. John's wort does not appear effective for treating ADHD in children and teens

Jun 10, 2008

Children and teens with attention-deficit/hyperactivity disorder (ADHD) who were treated with the herb St. John's wort did not have any greater improvement in ADHD symptoms compared to those who received placebo, according to a study in the June 11 issue of JAMA.

ADHD affects 3 to 12 percent of children in the United States. Up to 30 percent of these children do not respond to pharmaceutical medications or have adverse effects such as nausea, insomnia, or weight loss from the medications, according to background information in the article. "For these reasons, many parents seek complementary or alternative medicine for their children with ADHD.

Complementary or alternative medicine treatments used for pediatric ADHD include massage, dietary changes, dietary supplements, and herbal treatments. In the United States, the most common herbal treatments used by children with ADHD are St John's wort, Echinacea species, and Ginkgo biloba," the authors write.

Wendy Weber, N.D., Ph.D., M.P.H., of Bastyr University, Kenmore, Wash., and colleagues conducted a clinical trial of St. John's wort (Hypericum perforatum) with 54 children and adolescents with ADHD, age 6 to 17 years, to determine whether this agent was effective in lessening the severity of ADHD symptoms. Twenty-seven participants were randomly assigned to receive 300 mg of H perforatum standardized to 0.3 percent hypericin (a compound derived from H perforatum) and 27 participants received a matched placebo, three times daily for eight weeks. Other medications for ADHD were not allowed during the trial.

The researchers found that there were no significant differences between the two groups in the change in ADHD rating scale scores from the start of the trial to week 8 and in change in scores rating inattentiveness and hyperactivity. There was also no difference in the proportion of participants who were rated as much or very much improved regarding ADHD symptoms on another measurement scale. No statistically significant difference was found between the two groups in the proportion of participants who experienced 1 or more rash, nausea/vomiting, headache, or sunburn during the trial.

"To our knowledge, this is the first placebo-controlled trial of H perforatum in children and adolescents. The results of this study suggest that administration of H perforatum has no additional benefit beyond that of placebo for treating symptoms of child and adolescent ADHD," the authors write.

Citation: JAMA. 2008; 299[22]: 2633-2641.

Source: JAMA and Archives Journals

Explore further: Research identifies best treatment for blood pressure in diabetic kidney disease

Related Stories

New Japan volcano island 'natural lab' for life

55 minutes ago

A brand new island emerging off the coast of Japan offers scientists a rare opportunity to study how life begins to colonise barren land—helped by rotting bird poo and hatchling vomit.

Ecuador breaks Guinness reforestation record

10 hours ago

Ecuador broke the world record for reforestation Saturday, as thousands of people pitched in to plant 647,250 trees in a single day, President Rafael Correa said.

Turkey delays 4G tender after Erdogan confusion

10 hours ago

Turkey has delayed its planned tender for 4G mobile technology licences, reports said Saturday, after President Recep Tayyip Erdogan sowed confusion by saying the country should skip straight to 5G technology.

Recommended for you

CV autonomic neuropathy predicts urological issues

18 hours ago

(HealthDay)—For men with type 1 diabetes, cardiovascular autonomic neuropathy is associated with erectile dysfunction and/or lower urinary tract symptoms, according to a study published in the June issue ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.