The secret behind silkworm's hardy stomachs

May 27, 2008
Silkworm
Silkworm eating mulberry leaf. Credit: Toru Shimada

Silkworms have a unique ability to eat toxic mulberry leaves without feeling ill, and researchers have come one step closer to understanding why: silkworms contain a special digestive enzyme that is not affected by mulberry’s toxic chemicals.

Mulberry leaves contain an extremely high amount of alkaloids that inhibit enzymes that break down sucrose (sugar), and thus are potentially quite toxic. However, one type of sucrase called beta-fructofuranosidase is not affected by these alkaloids.

Until now, this enzyme has not been found in any animals, but Toru Shimada and colleagues believed this might explain the silkworm’s unique diet.

The researchers scanned the silkworm genome and discovered two fructofuranosidase genes, although only one was actually expressed in the worm. This gene (BmSuc1) was, as expected, concentrated in the worm’s gut, although surprisingly was also prevalent in the silk gland. When they isolated the enzyme from silkworms, the researchers found it could effectively digest sucrose.

Article URL: www.jbc.org/cgi/content/full/283/22/15271
The article appears in the May 30 Journal of Biological Chemistry.

Source: American Society for Biochemistry and Molecular Biology

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zevkirsh
not rated yet May 28, 2008
i want some of dat stuff

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