Identifying abnormal protein levels in diabetic retinopathy

May 12, 2008
Identifying abnormal protein levels in diabetic retinopathy
Scientists report new findings on diabetic retinopathy, a complication of diabetes that causes vision loss and blindness. Courtesy of U.S. National Library of Medicine, NIH

Researchers in Massachusetts are reporting an advance in bridging huge gaps in medical knowledge about the biochemical changes that occur inside the eyes of individuals with diabetic retinopathy (DR) — a leading cause of vision loss and blindness in adults. In a study scheduled for the June 6 issue of ACS’ monthly Journal of Proteome Research, they report discovery of 37 proteins that were increased or decreased in the eyes of patients with DR compared to patients without the disease.

Edward P. Feener and colleagues point out that DR is a complication of diabetes that affects the eyesight of millions of people. It involves damage to blood vessels in the retina, the light sensitive tissue in the back of the eye. Physicians know that vessels grow abnormally, swell, and leak in DR. However, they have little understanding of the biochemical changes underlying those damaging events.

The researchers studied eye fluid from individuals with and without DR who were undergoing eye surgery. They analyzed proteins in the vitreous, the gel-like material inside the eye between the retina and the lens. The study found 252 proteins in the fluid, including 37 proteins that showed changes that were associated with proliferative diabetic retinopathy, the most severe form of the disease.

The study could lead to new insights into disease mechanisms and new treatments, the article states.

Source: ACS

Explore further: 3D printing technique explored to help treat type 1 diabetes

Related Stories

Our bond with dogs may go back more than 27,000 years

10 minutes ago

Dogs' special relationship to humans may go back 27,000 to 40,000 years, according to genomic analysis of an ancient Taimyr wolf bone reported in the Cell Press journal Current Biology on May 21. Earlier genome ...

Recommended for you

Why Americans can't buy some of the best sunscreens

15 hours ago

With summer nearly here, U.S. consumers might think they have an abundance of sunscreen products to choose from. But across the Atlantic, Europeans will be slathering on formulations that manufacturers say provide better ...

Expanding the code of life with new 'letters'

15 hours ago

The DNA encoding all life on Earth is made of four building blocks called nucleotides, commonly known as "letters," that line up in pairs and twist into a double helix. Now, two groups of scientists are reporting ...

'Cold soak' process turns up the heat on wines

16 hours ago

Those pondering which elements make the best drop of wine may be surprised to learn different climates produce mixed results when it comes to wines made using the 'cold soak' process.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.