MDCT accurate in detecting stenosis in calcified coronary artery plaque

Apr 11, 2008

Multidetector CT angiography can accurately predict the presence of obstructive disease (stenosis) in small and moderate-sized calcified coronary artery plaque (CAP), and is even fairly accurate in diagnosing large and heavily calcified CAP, according to a recent study conducted by researchers at Thomas Jefferson University Hospital in Philadelphia, PA.

The study evaluated 31 patients who had one or more calcified CAP, comparing the results from CCTA to cardiac catheterization. “It is commonly believed that when coronary artery plaque is calcified, (particularly when it is heavily calcified), MDCT is unreliable in determining the degree of stenosis,” said David C. Levin, MD, lead author of the study. However, in this study CCTA and cardiac catheterization were concordant in 58 of 61 small calcified CAPs (95%), 20 of 22 moderate-sized (91%) and 29 of 43 large calcified CAPs (67%). The study showed that overestimation of stenosis occurred in 2 of the small lesions, 2 of the moderate-sized lesions and 14 of the large lesions.

“The results indicate that even when heavily calcified plaque is present, MDCT is pretty accurate in determining how much vessel narrowing it has caused. However, we have to recognize that when large and heavily calcified plaques are seen on MDCT, we tend to overestimate the degree of stenosis that results. This overestimation seems to be unavoidable in many cases,” said Dr. Levin.

Source: American Roentgen Ray Society

Explore further: Premature aging: Scientists identify and correct defects in diseased cells

Related Stories

Polysis is marketing a plastic that turns to clay

5 hours ago

Polysis is showing a plastic that can turn to clay when heated, according to a story on DigInfo TV. Polysis is described as a specialist developer of polyurethane resins and resin products, and they are marketing haplafreely, presented with a lower- ...

Wolfram's ID project launch touts ImageIdentify function

9 hours ago

You see a picture but you cannot name it. "What animal is this?" "Hmm, sort of looks like a guitar, not a cello—what is this instrument?" The Wolfram Language Identification Project was launched on Wednesday ...

Malaysian dam project opposed by tribes gets green light

9 hours ago

Construction of a Malaysian dam that will flood a rainforested area half the size of Singapore and displace 20,000 tribespeople was given the green light Saturday by the state government, local media reported.

Typhoon Dolphin looms over Guam

9 hours ago

Typhoon Dolphin passed through the Northern Marianas today just to the north of Guam with sustained winds estimated at 95 knots (~109 mph) by the Joint Typhoon Warning Center (JTWC). The center passed through ...

Recommended for you

Scientists turn blood into neural cells

May 21, 2015

Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.