Toward a new generation of vaccines for malaria and other diseases

March 24, 2008

Researchers in Colombia, South America, describe a new strategy for designing the next generation of synthetic vaccines that could lead to more effective treatments for fighting malaria, tuberculosis, AIDS and other infectious diseases. These conditions kill more than 17 million people around the world each year. Their study appears in the current issue of ACS’ Accounts of Chemical Research.

Traditional vaccine development involves the use of microorganisms to trigger an immune response by the body. However, this approach can produce unwanted side effects and may be ineffective against microbes with extremely complex infection cycles. Therefore, researchers agree on the need for better vaccine.

In the study, Manuel E. Patarroyo and his son Manuel A. Patarroyo describe a completely new strategy for designing more effective vaccines, which are chemically synthesized in the laboratory without the use of microorganisms. They identified dozens of key protein fragments involved in the complex infection process of the malaria parasite, from which they designed, specifically modified and synthesized chemically some of the most promising malaria vaccine candidates that have been tested to date.

Likewise, identifying the disease-related protein fragments involved in the complex infection process of other transmittable diseases could result in new, more effective vaccines to help fight these diseases, the scientists say. They also note that this innovative approach establishes for the first time the emerging rules for the development of vaccines against diseases scourging humankind.

Source: ACS

Explore further: Comoros say on the cusp of eradicating malaria

Related Stories

Comoros say on the cusp of eradicating malaria

November 22, 2016

Though victory is yet to be officially declared, Comoros health authorities believe the three islands of the Indian Ocean archipelago are on the cusp of being malaria-free.

Recommended for you

Egyptian mummies virtually unwrapped in Australia

December 8, 2016

The hidden secrets of Egyptian mummies up to 3,000 years old have been virtually unwrapped and reconstructed for the first time using cutting-edge scanning technology in a joint British-Australian exhibition.

Dark matter may be smoother than expected

December 7, 2016

Analysis of a giant new galaxy survey, made with ESO's VLT Survey Telescope in Chile, suggests that dark matter may be less dense and more smoothly distributed throughout space than previously thought. An international team ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.