Researcher studies drug-resistant bacteria in environment

March 19, 2008
Researcher studies drug-resistant bacteria in environment
Lesley Warren, associate professor in the School of Geography & Earth Sciences. Photo by Susan Bubak.

Water is essential to life, but the water we drink to stay alive could also be making us sick. Lesley Warren, associate professor in the School of Geography & Earth Sciences, is studying the interaction between water, rocks and bacteria that can have a negative impact on human and environmental health.

"Environmental water quality and public health are inextricably linked," said Warren.

She is currently studying the link between antibiotic resistance in environmental bacteria and water quality. Bacteria have been around for 3.5 billion years, and they have learned how to survive by adapting to their environment, Warren explained. However, when bacteria develop resistance to contaminants in their environment, such as heavy metals, that resistance often works against antibiotics.

Environmental bacteria are also directly exposed to drugs through treated water discharges and agricultural runoff, which can lead to resistance.

A recent investigation by the Associated Press found trace amounts of various pharmaceuticals, including antibiotics, painkillers and hormones, in drinking water supplied to a number of American cities. The quantities of drugs were so miniscule, they passed through water treatment facilities. Once bacteria develop resistance to a particular drug, they pass on the resistance to their siblings, offspring and other bacteria.

Last summer, in a pilot study supported by McMaster's Collaborations for Health, Warren and colleagues Christian Baron (Biology) and Padman Jayaratne (Pathology and Molecular Medicine), collected bacteria samples from Toronto's Sunnyside beach and found them to be resistant to antibiotics. But developing new, more powerful drugs isn't the answer.

"You're never going to stop resistance," said Warren. "It's a natural process. Looking for new drugs is a race we're not winning." By understanding how and when resistance is triggered by environmental conditions, researchers can develop more effective early warning indicators and provide new ideas for therapeutic strategies to combat infectious diseases.

Warren is leading an NSERC Strategic Project that includes Gerry Wright, director of the Michael G. DeGroote Institute for Infectious Disease Research, researchers from other universities, Environment Canada, a team of graduate and undergraduate students, as well as public health officers in Hamilton and Toronto to develop an early warning system that would identify when environmental conditions are ripe for developing drug-resistant bacteria that could pose a threat to human health.

In one of the first environmental surveillance studies for the province, the group will start evaluating both water quality and the occurrence of antibiotic resistance in bacteria in water bodies around Ontario this summer.

Source: McMaster University

Explore further: Parasitic plants may form weapons out of genes stolen from hosts

Related Stories

Where is the science of Zika virus control?

October 19, 2016

Zika virus infection is a devastating disease for its association with neurological disorders (Guillain-Barré syndrome and microcephaly). For the last few months Zika virus has spread at a rapid pace over the continent of ...

Researchers find new way to attack gastro bug

October 21, 2016

A team at Griffith's Institute for Glycomics identified a unique sensory structure that is able to bind host-specific sugar and is present on particularly virulent strains of Campylobacter jejuni.

A lead to overcome resistance to antibiotics

October 6, 2016

Pseudomonas aeruginosa can become a formidable pathogen causing fatal infections, especially in intubated patients, people suffering from cystic fibrosis or severe burns. The presence of certain metals in the natural or human ...

Recommended for you

Shocks in the early universe could be detectable today

October 27, 2016

(—Physicists have discovered a surprising consequence of a widely supported model of the early universe: according to the model, tiny cosmological perturbations produced shocks in the radiation fluid just a fraction ...

Bubble nucleus discovered

October 27, 2016

Research conducted at the National Superconducting Cyclotron Laboratory at Michigan State University has shed new light on the structure of the nucleus, that tiny congregation of protons and neutrons found at the core of ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.