New method for the production of defined microparticles with 3-D nanopatterns

November 15, 2007

Many scientists are working feverishly to develop reliable but simple methods for the production of tiny particles with defined size and shape that are covered with special regular patterns in two or three dimensions and at both the nano- and the microscale. These miniature objects have countless applications in modern technology, from diagnostic systems to the generation of artificial tissues to improved data storage.

A team headed by Edwin L. Thomas and Patrick S. Doyle at MIT in Cambridge, Massachusetts (USA) has now developed a new method for the large-scale synthesis of three-dimensionally patterned polymer particles with morphological characteristics in the submicrometer range. As described in the journal Angewandte Chemie, with the use of stop-flow interference lithography, the team has even been able to produce Janus particles, microparticles with two chemically different hemispheres.

“Our new method is a combination of phase mask interference lithography and mirofluidic flow lithography, unifying the strengths of these two methods,” explain the researchers. Liquid precursors of a polymer whose formation is induced by light are introduced into a microfluidic system (a system of channels that are just a few micrometers wide). The bottom portion of the device is a phase mask with a periodic surface structure.

This arrangement is irradiated through a transparency mask that defines the shape of the resulting particles. In a test sample these were triangles with sides of 60 µm. Once the parallel light rays pass through the strictly periodic surface structure of the phase mask, the result is a complex three-dimensional distribution of light intensity within the liquid (interference).

In regions of high intensity, the polymer precursors are cross-linked to form three-dimensional structures in a solid hydrogel. In this way, the researchers were able to give the triangular particles a knobby, lattice-like structure.

Because this method works continuously, it can attain a very high throughput: Liquid flows in and polymerizes to form particles that are immediately rinsed away when the next portion of liquid follows—all in less than a second. In contrast to other techniques, the liquid does not need to be deposited in an even layer on a support and developed stepwise.

In addition, within a microchannel, it is possible to allow two different liquids to flow side by side without mixing. If the transparency mask is adjusted so that the light irradiates a region around the boundary between the two liquids, the process results in Janus particles with two chemically different hemispheres.

Citation: Edwin L. Thomas, A Route to Three-Dimensional Structures in a Microfluidic Device: Stop-Flow Interference Lithography, Angewandte Chemie International Edition 2007, 46, No. 47, 9027–9031, doi: 10.1002/anie.200703525

Source: Wiley

Explore further: SLAC gears up for dark matter hunt with LUX-ZEPLIN

Related Stories

SLAC gears up for dark matter hunt with LUX-ZEPLIN

May 21, 2015

Researchers have come a step closer to building one of the world's best dark matter detectors: The U.S. Department of Energy (DOE) recently signed off on the conceptual design of the proposed LUX-ZEPLIN (LZ) experiment and ...

Researchers find a new way to clear the air

March 17, 2015

In 1999, then-Chinese Premier Zhu Rongji said that Beijing's pall of smog "would shorten my life at least five years," a hazard level scientists affirmed two years ago with a study of China's air pollution. That reality that ...

ACEs are high with space station colloidal research

August 25, 2014

One global marketer took to space to find a way to be leaner and greener back on Earth. For Procter & Gamble (P&G), product innovation and improvement relied on use of the International Space Station (ISS) as a science platform ...

Recommended for you

Making nanowires from protein and DNA

September 3, 2015

The ability to custom design biological materials such as protein and DNA opens up technological possibilities that were unimaginable just a few decades ago. For example, synthetic structures made of DNA could one day be ...

Graphene made superconductive by doping with lithium atoms

September 2, 2015

(Phys.org)—A team of researchers from Germany and Canada has found a way to make graphene superconductive—by doping it with lithium atoms. In their paper they have uploaded to the preprint server arXiv, the team describes ...

For 2-D boron, it's all about that base

September 2, 2015

Rice University scientists have theoretically determined that the properties of atom-thick sheets of boron depend on where those atoms land.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.