In the laboratory, green tea proves a powerful medicine against severe sepsis

Nov 08, 2007

A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection.

In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis – and the findings could pave the way to clinical trials in patients.

The study was published this week in the Public Library of Science, or PLoS-ONE. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.

Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis – both on the basic biological level and in patients.

In the latest study, Dr. Wang’s group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn’t receive the green tea substance to 82 percent in those who did. “Clinically, even if we could save five percent of patients, that would be huge,” said Dr. Wang. “In this study, we saved 25 percent more animals with the green tea.” He said that the green tea component, EGCG, is readily available.

There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. “This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines,” he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. “We are hoping to stimulate future interest in clinical studies,” said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.

Source: North Shore-Long Island Jewish Health System

Explore further: Health professionals may view family-witnessed CPR negatively

Related Stories

Former federal agent pleads guilty to stealing bitcoins

1 hour ago

A former undercover federal agent pleaded guilty to extortion and related charges after acknowledging he channeled more than $700,000 in digital currency from the Silk Road online drug bazaar he was investigating.

Cities, regions, demand bigger climate say

1 hour ago

Leaders of city and regional governments gathered Wednesday in the French city of Lyon, in the grips of a western European heatwave, to demand a bigger stake in the global push to curb global warming.

Hewlett-Packard moves forward with plan to split in two

1 hour ago

Hewlett-Packard is moving forward with plans to split into two companies, filing paperwork to create a new entity that will sell commercial technology, while a separate spinoff will sell personal computers and printers.

Recommended for you

Asian-language smoking quitline successful nationwide

3 hours ago

(HealthDay)—An Asian-Language Smokers Quitline (ASQ) reaches Chinese, Korean, and Vietnamese speakers nationwide, and most callers receive medication and counseling, according to a study published online ...

Many Americans trying to cut their salt intake: CDC

3 hours ago

(HealthDay)—Worried about links between high daily salt intake, high blood pressure and stroke, half of American adults questioned in a recent poll say they've tried to cut back on sodium.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.