Guardian of genome predicts treatment outcomes for childhood cancer

Nov 05, 2007

Researchers have identified a new role for a cancer-prevention gene in the response to drug treatment for childhood cancer.

In humans, the p53 tumour suppressor gene, also known as the ‘guardian of the genome’, is known for its role in the prevention of cancer. Mutations in the gene are associated with a high incidence of cancer due to the uncontrolled division of cells which give rise to tumours.

In childhood cancers such as neuroblastoma, p53 mutations are rare at diagnosis, however they can emerge after chemotherapy.

A recent study published in the international journal Cancer Research this month by researchers from the Children’s Cancer Institute Australia for Medical Research (CCIA), and collaborators in the USA, describes a new role for p53 in childhood cancer.

The group showed that by inactivating p53 in neuroblastoma cells, the most common childhood cancer, the cancer cells became resistant to a number of chemotherapy drugs.

“Our results provide definitive evidence of a role for p53 as a gene which dictates drug sensitivity in neuroblastoma,” said Dr Xue of CCIA’s Molecular Diagnostics Program.

Source: Research Australia

Explore further: Spicy treatment the answer to aggressive cancer?

Related Stories

MicroRNA to combat cancer

Sep 28, 2010

(PhysOrg.com) -- Researchers from the Queensland Institute of Medical Research, the Garvan Institute of Medical Research and the University of California-San Francisco have found a new way to kill cancer cells, opening the ...

Cancer breakthrough could save children’s lives

Feb 17, 2010

(PhysOrg.com) -- A cancer which claims the lives of thousands of children worldwide every year is a step closer to being cured thanks to a breakthrough by scientists at Newcastle University.

Recommended for you

Spicy treatment the answer to aggressive cancer?

22 hours ago

It has been treasured by food lovers for thousands of years for its rich golden colour, peppery flavour and mustardy aroma…and now turmeric may also have a role in fighting cancer.

Cancer survivors who smoke perceive less risk from tobacco

Jul 02, 2015

Cancer survivors who smoke report fewer negative opinions about smoking, have more barriers to quitting, and are around other smokers more often than survivors who had quit before or after their diagnosis, according to a ...

Melanoma mutation rewires cell metabolism

Jul 02, 2015

A mutation found in most melanomas rewires cancer cells' metabolism, making them dependent on a ketogenesis enzyme, researchers at Winship Cancer Institute of Emory University have discovered.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.