New study shows that therapeutic gene expression can be sustainable for 1 year

Oct 26, 2007

Researchers at the Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have shown for the first time that it is possible to sustain therapeutic gene expression in the central nervous system for up to a year, even in the presence of an anti-viral immune response mechanism that is normally present in humans.

The researchers demonstrated in an animal model that the delivery system for the gene, a novel gutted adenoviral vector called HC-Adv, is completely invisible to the immune system. Vectors previously used to deliver genes carried minute amounts of viral proteins that were detected by the immune system, triggering an immune response that rendered the therapeutic gene inactive after a period of weeks.

According to the researchers, this delivery system is safer and more effective than what is currently available, and should therefore advance clinical gene therapy trials for people suffering from central nervous system disorders such as Parkinson’s, Alzheimer’s, and Multiple Sclerosis. The research was sponsored in part by The National Institutes of Health.

Source: Cedars-Sinai Medical Center

Explore further: Team discovers key step in how taste buds regenerate

Related Stories

Key element in bacterial immune system discovered

Apr 20, 2015

A University of Otago scientist is a member of an international research team that has made an important discovery about the workings of a bacterial immune system. The finding could lead to the development ...

How Salmonella survives the macrophage's acid attack

Apr 14, 2015

Macrophages destroy bacteria by engulfing them in intracellular compartments, which they then acidify to kill or neutralize the bacteria. However, some pathogenic bacteria, such as Salmonella enterica, have evolved ...

How a deadly fungus evades the immune system

Mar 31, 2015

New research from the University of Toronto has scientists re-thinking how a lethal fungus grows and kills immune cells. The study hints at a new approach to therapy for Candida albicans, one of the most c ...

Recommended for you

Team discovers key step in how taste buds regenerate

May 28, 2015

Researchers at the University of Colorado Anschutz Medical Campus have discovered a key molecular pathway that aids in the renewal of taste buds, a finding that may help cancer patients suffering from an ...

How mutations in a high risk gene affect motor neurons

May 28, 2015

Scientists at the flagship motor neuron disease research centre, based at the University of Sheffield, investigated how specialised nerve cells that control voluntary movements die – something which is ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.