Pregnant mom's exposure to flu vaccine kick-starts fetal immune system

Jun 01, 2007

Some researchers have hypothesized that the fetus can be exposed to and mount an immune response against allergens to which the mother has been exposed, and this may have an effect on the development of allergic sensitivity (e.g. eczema and asthma) later in an infant’s life. However this hypothesis has remained controversial because of an inability to detect antigen-specific T cells in cord blood. Recently, a newly developed technique known as MHC tetramer staining has facilitated the detection of antigen-specific T cells.

In the June 1 issue of the Journal of Clinical Investigation, a team of researchers led by Rachel Miller from Columbia University used this technique to study cord blood B and T cell immune responses following maternal vaccination against influenza with Fluzone during pregnancy.

The vaccination of pregnant women against influenza is considered safe and is recommended by the Centers for Disease Control and Prevention. The authors detected anti-Fluzone antibodies in approximately 40% of cord blood specimens examined. These results and further data reported in the study establish that B and T cell responses to antigens occur in utero following maternal vaccination against influenza, supporting the theory that the human neonatal immune system is not deficient or incompetent but, rather, capable of responding to environmental exposures.

These conclusions have important implications for determining when immune responses to environmental exposures begin.

Source: Journal of Clinical Investigation

Explore further: Court clears German safety body in breast implant scare

Related Stories

Single-cell technologies advance the value of genomics

Jun 24, 2015

Biologists are looking to extract as much information as possible from small amounts of valuable biological material, and to understand biological responses at higher levels of resolution. The Genome Analysis ...

Recommended for you

Drug and device firms paid $6.5B to care providers

Jun 30, 2015

From research dollars to free lunches and junkets, drug and medical device companies paid doctors and leading hospitals nearly $6.5 billion last year, according to government data posted Tuesday.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.