Technology monitors myriad molecules

May 7, 2007

A U.S. scientist has created a computer chip consisting of thousands of electrodes yielding molecules that bind to receptor sites.

Chemistry Professor Kevin Moeller of Washington University in St. Louis said the electrodes on the chip can be used to monitor the biological behavior of up to 12,000 molecules at the same time.

Moeller and colleagues are pioneering new methods for building libraries of small molecules on addressable electrode arrays so the molecules can be monitored in real-time and, in turn, used to probe the binding requirements of drug receptor sites.

The electrochemically addressable chips represent a new environment for synthetic organic chemistry, he said, changing the way chemists and biomedical researchers make molecules, build molecular libraries and understand the mechanisms by which molecules bind to receptor sites.

"We believe we can move most of modern synthetic organic chemistry to this electrochemically addressable chip," said Moeller. "It's a tool, still being developed, to map receptors. We're right at the cusp of things."

Moeller discussed the technology in a recent article in the Journal of the American Chemical Society and presented his work Monday in Chicago during the 211th National Meeting of the Electrochemistry Society.

Copyright 2007 by United Press International

Explore further: Researchers design and patent graphene biosensors

Related Stories

Researchers design and patent graphene biosensors

November 13, 2015

The Moscow Institute of Physics and Technology (MIPT) is patenting biosensor chips based on graphene, graphene oxide and carbon nanotubes that will improve the analysis of biochemical reactions and accelerate the development ...

Measuring molecules with the naked eye

October 26, 2012

When someone develops liver cancer, the disease introduces a very subtle difference to their bloodstream, increasing the concentration of a particular molecule by just 10 parts per billion.

Grafting olfactory receptors onto nanotubes

July 26, 2011

( -- Penn researchers have helped develop a nanotech device that combines carbon nanotubes with olfactory receptor proteins, the cell components in the nose that detect odors.

Building a biochemistry lab on a chip

February 12, 2013

(—Miniaturized laboratory-on-chip systems promise rapid, sensitive, and multiplexed detection of biological samples for medical diagnostics, drug discovery, and high-throughput screening. Using micro-fabrication ...

In a new microchip, cells separate by rolling away

February 24, 2012

Cell rolling is a common mechanism cells use to navigate through the body. During inflammation, for example, the endothelial cells that line blood vessels present certain molecules that attract white blood cells just enough ...

Recommended for you

Moonlighting molecules: Finding new uses for old enzymes

November 27, 2015

A collaboration between the University of Cambridge and MedImmune, the global biologics research and development arm of AstraZeneca, has led researchers to identify a potentially significant new application for a well-known ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.