Common genetic variation is linked to substantial risk for heart attack

May 4, 2007

A common genetic variation on chromosome 9p21 is linked to a substantial increase in risk for heart attack, according to a new international research study. The findings are published in the online edition of Science, and will appear in an upcoming printed edition of the journal.

Researchers found individuals with the variation have a 1.64-fold greater risk of suffering a heart attack (myocardial infarction) and a 2.02-fold greater risk of suffering a heart attack early in life (before age 50 for men and before age 60 for women) than those without the variation. Approximately 21 percent of individuals of European descent carry two copies of the genetic variation (one from each parent), found on chromosome 9p21.

The research project was led by the Icelandic genomics company deCODE Genetics, along with U.S. researchers at Emory University School of Medicine, Duke University, and the University of Pennsylvania.

Myocardial infarction is the death of heart tissue that results when the blood supply to the heart is cut off. It is the leading cause of death in the industrialized world. Nearly half of men and one-third of women who reach the age of 40 will suffer a heart attack in their lifetime.

The study led by deCODE Genetics uncovered the first common variant found to be consistently linked to substantial risk of heart attack in multiple case-control groups of European descent.

The researchers found a population-attributable risk for heart attack of 21 percent in general and of 31 percent for early onset cases. This means that were the gene variant not present, there would be 21 percent fewer heart attacks overall in the population and 31 percent fewer early onset heart attacks.

"The gene variant we have linked to heart attack points us to a major biological mechanism that substantially increases the risk," explains Emory cardiologist Arshed A. Quyyumi, MD, one of the study authors. "Discoveries like this one greatly heighten our understanding of the role genetics plays in heart disease."

Source: Emory University

Explore further: Researcher to talk at Black Hat on 'scary' area in Android

Related Stories

Researcher to talk at Black Hat on 'scary' area in Android

July 28, 2015

Does that cute little green robotic creature with two ear-sticks call up feelings of an open, friendly mobile operating system, aka Android? Wow, Monday stories were not about how cute and adorable is that little green creature. ...

Wearable fitness devices carry security risks

August 5, 2015

During a 2014 competition among Netflix employees to create potential new features, one group hacked into a Fitbit and created a "Sleep Bookmark" function, automatically pausing Netflix as the wearer started to fall asleep.

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

( -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.