New treatment yields complete regression of a human cancer in mice

April 23, 2007

A simple modification in an anti-cancer treatment currently in clinical trials substantially improves the drug’s effectiveness and reduces side effects in experiments with laboratory mice, researchers are reporting in an article scheduled for the May 16 edition of ACS’ Bioconjugate Chemistry. Enzon Pharmaceuticals’ David Filpula and colleagues at the National Cancer Institute worked on SS1P, a so-called immunotoxin that targets and destroys cells producing the surface protein mesothelin.

Ovarian, pancreatic and malignant mesothelioma cells all produce abnormally large amounts of mesothelin and thus are targets for SS1P. In the new study, researchers modified SS1P with PEGylation, which involves attaching chains of polyethylene glycol (also known as PEG) to the molecule. PEGylation is a well-established process that is used in at least six protein-based pharmaceutical products currently on the market.

PEGylated SS1Ps had fewer side effects and were more effective in mice bearing human tumors than standard SS1P, the report states. A single dose of the modified SS1P resulted in complete regression of the mouse tumors, the first time that such an effect had been observed, the researchers said. PEGylation of SS1P and other immunotoxins may hold promise for use in cancer patients, as well, they added.

Source: ACS

Related Stories

Recommended for you

Internet giants race to faster mobile news apps

October 4, 2015

US tech giants are turning to the news in their competition for mobile users, developing new, faster ways to deliver content, but the benefits for struggling media outlets remain unclear.

The dark side of Nobel prizewinning research

October 4, 2015

Think of the Nobel prizes and you think of groundbreaking research bettering mankind, but the awards have also honoured some quite unhumanitarian inventions such as chemical weapons, DDT and lobotomies.

Trade in invasive plants is blossoming

October 3, 2015

Every day, hundreds of different plant species—many of them listed as invasive—are traded online worldwide on auction platforms. This exacerbates the problem of uncontrollable biological invasions.

En route to CEATEC: 17.3-inch 8K4K LCD module

October 3, 2015

In the old days, people were impressed if a screen image simply was not blurry. "Clear" was the supreme compliment. We know the rest. Technology advances have raised consumer expectations; a competitive vendor in electronics ...

Fusion reactors 'economically viable' say experts

October 2, 2015

Fusion reactors could become an economically viable means of generating electricity within a few decades, and policy makers should start planning to build them as a replacement for conventional nuclear power stations, according ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.