Just how useful are animal studies to human health?

December 15, 2006

Animal studies are of limited usefulness to human health because they are of poor quality and their results often conflict with human trials, argue researchers in a study on bmj.com today.

Before clinical trials are carried out, the safety and effectiveness of new drugs are usually tested in animal models. Some believe, however, that the results from animal trials are not applicable to humans because of biological differences between the species.

So researchers compared treatment effects in animal models with human clinical trials.

They used systematic reviews (impartial summaries of evidence from many different studies) of human and animal trials to analyse the effects of six drugs for conditions such as head injury, stroke and osteoporosis.

Agreement between human and animal studies varied. For example, corticosteroids did not show any benefit for treating head injury in clinical trials but did show a benefit in animal models. Results also differed for the drug tirilazad to treat stroke - data from animal studies suggested a benefit but the clinical trials showed no benefit and possible harm.

Some results did agree. For instance, bisphosphonates increased bone mineral density in both clinical trials and animal studies, while corticosteroids reduced neonatal respiratory distress syndrome in animal studies and in clinical trials, although the data were sparse.

Animal studies are generally of poor quality and lack agreement with clinical trials, which limits their usefulness to human health, say the authors. This discordance may be due to bias, random error, or the failure of animal models to adequately represent clinical disease.

Systematic reviews could help translate research findings from animals to humans. They could also promote closer collaboration between the research communities and encourage an interative approach to improving the relevance of animal models to clinical trial design, they conclude.

Source: British Medical Journal

Explore further: Use of antivirals in retrovirus-infected cats

Related Stories

Use of antivirals in retrovirus-infected cats

November 24, 2015

A number of antiviral drugs are licensed and widely used for the treatment of specific viral infections in humans. Potential new agents are also being investigated that it is hoped will overcome limitations of the current ...

Oxytocin nose-drop brings marmoset partners closer

October 14, 2015

Researchers from the University of Nebraska at Omaha, show for the first time that common marmosets—Callithrix jacchus, a species of New World monkey—that receive oxytocin in nose-drops attract more social interaction ...

Have your drug nano-delivered via microbubble

October 12, 2015

"Colloidal delivery system" and "nanoparticle" are probably not terms you find yourself using in day-to-day interactions, but for UC's Yoonjee Park, assistant professor in the College of Engineering and Applied Science biomedical ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.