Scientists report thyroid cancer discovery

Nov 15, 2006

Canadian scientists say the discovery of a mutated protein in cells linked with thyroid cancer may lead to the development of drugs to fight such cancers.

"We now know why this gene causes these tumors and can start looking at how best to target the mutant proteins so that the cells expressing them can be killed or stopped from growing," said Queens University pathology and molecular medicine Professor Lois Mulligan, senior author of the study.

She and graduate student Taranjit Gujral developed three-dimensional models of the mutated RET protein implicated in a condition causing cancerous thyroid tumors. The model allowed them to predict and compare the protein's molecular actions and to see that the protein was 10 times more active than normal in cells associated with Multiple Endocrine Neoplasia 2B syndrome, an inherited cancer syndrome.

Vinay Singh and Zongchao Jia of the university's biochemistry department were co-authors of the study that appears in the journal Cancer Research.

Copyright 2006 by United Press International

Explore further: Mammography benefits overestimated, review says

Related Stories

Recommended for you

Mammography benefits overestimated, review says

8 hours ago

An in-depth review of randomised trials on screening for breast, colorectal, cervical, prostate and lung cancers, published in the Journal of the Royal Society of Medicine, shows that the benefits of mammographic screening are li ...

Extended-field IMRT does not increase duodenal toxicity risk

10 hours ago

A study of women with cervical or endometrial cancer who require treatment to the para-aortic (PA) lymph nodes can safely receive extended-field intensity modulated radiation therapy (EF-IMRT) without increased risk of duodenal ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.