Scientists report thyroid cancer discovery

November 15, 2006

Canadian scientists say the discovery of a mutated protein in cells linked with thyroid cancer may lead to the development of drugs to fight such cancers.

"We now know why this gene causes these tumors and can start looking at how best to target the mutant proteins so that the cells expressing them can be killed or stopped from growing," said Queens University pathology and molecular medicine Professor Lois Mulligan, senior author of the study.

She and graduate student Taranjit Gujral developed three-dimensional models of the mutated RET protein implicated in a condition causing cancerous thyroid tumors. The model allowed them to predict and compare the protein's molecular actions and to see that the protein was 10 times more active than normal in cells associated with Multiple Endocrine Neoplasia 2B syndrome, an inherited cancer syndrome.

Vinay Singh and Zongchao Jia of the university's biochemistry department were co-authors of the study that appears in the journal Cancer Research.

Copyright 2006 by United Press International

Explore further: Scientists seek answers with space station thyroid cancer study

Related Stories

Genomic 'markers' may head off thousands of thyroid surgeries

November 23, 2010

Doctors at the University of Colorado School of Medicine were concerned recently when they found a nodule in the thyroid of a 64-year-old Colorado man. They extracted cells from the nodule, hoping to determine whether the ...

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

( -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.