Gene's cancer role is identified

August 8, 2006

U.S. medical researchers say they've discovered a new cancer-promoting role for a gene potentially linked with breast, liver and other kinds of cancer.

The scientists at Harvard Medical School and Massachusetts General Hospital say their discovery that the gene YAP can transform mammary epithelial cells opens the door to understanding how a novel cell growth controlling pathway first discovered in fruit flies might be important in human cancers.

"We screened the DNA from breast cancer cells for amplifications that are associated with tumor development," said senior author Dr. Daniel Naber, a professor of medicine and director of the MGH Cancer Center. "The identification of these new potential cancer-causing genes is critical to uncovering novel pathways that drive the conversion of a normal cell to a cancerous one.

The research was conducted jointly by Haber and Joan Brugge, a biology professor at HMS.

The findings appear in the online early edition of the Proceedings of the National Academy of Sciences and will appear in the Aug. 15 print edition.

Copyright 2006 by United Press International

Explore further: Discovery of a novel Wnt inhibitor with potential to eradicate colorectal cancer stem cells

Related Stories

Mitosis study finds potential cancer target

August 30, 2016

Structural biologists show in a new study that an apparently key step in the process of cell division depends on a unique interaction among specific proteins, including one that is strongly linked to cancer. Their hope now ...

DNA chip offers big possibilities in cell studies

August 25, 2016

A UT Dallas physicist has developed a novel technology that not only sheds light on basic cell biology, but also could aid in the development of more effective cancer treatments or early diagnosis of disease.

Recommended for you

Thunderstorms spread mercury pollution

August 31, 2016

In the southern United States, an afternoon thunderstorm is part of a regular summer day. But new research shows those storms might be doing more than bringing some scary thunder and lightning.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.