Drug may be alternative to castration

August 23, 2006

U.S. medical scientists have found an oral drug is an acceptable alternative to chemical castration to treat prostate cancer.

"In patients with locally-advanced disease, a daily 150 mg dose of bicalutamide (Casodex) following initial radiotherapy has shown significant clinical benefits in terms of overall survival and progression-free survival, compared with radiotherapy alone," said study author Dr. William See, chairman and professor of urology at the Medical College of Wisconsin and chief of urologic surgery at Milwaukee's Froedtert Hospital.

The double-blind, randomized study followed 1,370 early prostate cancer patients who received radiotherapy with curative intent. After a median follow-up of 7.2 years, the researchers found those receiving the daily Casodex regimen reduced their risk of disease progression by 44 percent, and overall risk of death by 35 percent, compared with those receiving a placebo.

"Although many of the adverse effects of castration therapy are manageable, they can have a detrimental effect on quality of life," said See "Here we have evaluated the efficacy and tolerability of a non-castration-based therapy, and found the survival rates to be similar."

The study appears in the Journal of Cancer Research and Clinical Oncology.

Copyright 2006 by United Press International

Explore further: New tests provide assurance to MRI-guided radiotherapy

Related Stories

New tests provide assurance to MRI-guided radiotherapy

September 16, 2015

Researchers from the National Physical Laboratory (NPL), VSL and the University of Michigan have taken a crucial step towards accurate dosimetry for MRI-guided radiotherapy - a state-of-the-art cancer treatment.

Surviving breast cancer -- low-income females worst hit

October 14, 2009

Later diagnosis, less first-course treatment and race are the main reasons for the difference in mortality between rich and poor breast cancer patients. A new study, published in the open access journal BMC Cancer, suggests ...

Recommended for you

A quantum of light for materials science

December 1, 2015

Computer simulations that predict the light-induced change in the physical and chemical properties of complex systems, molecules, nanostructures and solids usually ignore the quantum nature of light. Scientists of the Max-Planck ...

Exiled exoplanet likely kicked out of star's neighborhood

December 1, 2015

A planet discovered last year sitting at an unusually large distance from its star - 16 times farther than Pluto is from the sun - may have been kicked out of its birthplace close to the star in a process similar to what ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.