'Land of the ever-young' gene reprogrammes cells

June 14, 2006

University of Edinburgh scientists have discovered that the “ever-young” gene Nanog can cause adult cells to switch back to an embryonic state. The finding, to be published in the prestigious journal Nature, is the first to show that a specific gene affects the reprogramming of a mature cell type into a naïve state. The Edinburgh team believe this is a promising step towards understanding how to promote regeneration of damaged tissues and organs using a person’s own cells.

The team of scientists, lead by Professor Austin Smith at the Institute for Stem Cell Research, investigated the switching of adult cell types into embryonic stem cells after cell fusion. Fusion is the combination of two cells to form a single hybrid cell. Like nuclear transfer, the cloning process used to create Dolly the sheep, cell fusion can reprogramme the genetic information in a specialised cell to a naïve embryonic state. But this occurs very rarely. Says Professor Smith, “We set out to identify genes that could make reprogramming more efficient – our first candidate was Nanog because of its special role in formation of the early embryo and embryonic stem cells”.

The Edinburgh scientists fused mouse embryonic stem cells with brain stem cells, a type of adult stem cell. They found that the addition of Nanog resulted in a massive increase in the numbers of hybrid cells, all of which behaved like embryonic stem cells. Most importantly the hybrid cells showed the capacity to make many different cell types, such as heart and gut. “This means that the genetic programme of the brain cells has been erased and replaced by the unspecialised programme of an early embryo cell” says Dr Jose Silva, first author of this study.

Dr Silva adds “The effect of Nanog is remarkable. All of the hybrid cells become fully converted to embryonic stem cells. If we can figure out how Nanog does this, it may become possible to switch cell types without fusion or cloning.” However, the Edinburgh team must also identify at least one other key gene. “Nanog has great power” says Professor Smith, “but it does not work in isolation, only in partnership with other genes present in embryonic stem cells”.

This research was supported by the Biotechnology and Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC) and The Wellcome Trust. Jose Silva was a Long-term Fellow of the European Molecular Biology Organisation (EMBO).

Citation: Silva, J, Chambers, I, Pollard, S and Smith, A (2006) Nanog promotes transfer of pluripotency after cell fusion. Nature doi:10.1038/nature04914

Source: Nature

Explore further: Technology helps personalized medicine, enabling epigenomic analysis with a mere 100 cells

Related Stories

New material forges the way for 'stem cell factories'

July 22, 2015

If you experience a major heart attack the damage could cost you around five billion heart cells. Future stem cell treatments will require this number and more to ensure those cells are replaced and improve your chances of ...

Sex among eukaryotes is far more common than once believed

July 28, 2015

(Phys.org)—For a long time, biologists have considered sex to be an inherent trait of multicellular life, while microbial eukaryotes were considered to be either optionally sexual or purely clonal. From this perspective, ...

Recommended for you

First detection of lithium from an exploding star

July 29, 2015

The chemical element lithium has been found for the first time in material ejected by a nova. Observations of Nova Centauri 2013 made using telescopes at ESO's La Silla Observatory, and near Santiago in Chile, help to explain ...

Researchers discover new type of mycovirus

July 29, 2015

Researchers, led by Dr Robert Coutts, Leverhulme Research Fellow from the School of Life and Medical Sciences at the University of Hertfordshire, and Dr Ioly Kotta-Loizou, Research Associate at Imperial College, have discovered ...

Rogue wave theory to save ships

July 29, 2015

Physicists have found an explanation for rogue waves in the ocean and hope their theory will lead to devices to warn ships and save lives.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.