Major Kaposi's sarcoma discovery announced

April 6, 2006

Government scientists say they've found a human cell surface molecule involved with the Kaposi's sarcoma herpes virus.

The researchers at the National Institute of Allergy and Infectious Disease say the molecule xCT is a major gateway the herpes virus uses to enter human cells and might also play a role in the development of Kaposi's sarcoma and other syndromes associated with the virus.

The natural function of xCT is to transport molecules necessary for protecting against stress into cells. When cells are stressed, they express more xCT. Such stress can be caused by KSHV itself and that, scientists say, suggests the virus may cause itself to be more effective.

"Understanding the mechanisms of cell entry of Kaposi's sarcoma herpes virus is a landmark achievement in and of itself," said NIAID Director Dr. Anthony Fauci. "But the connection between the virus and expression of its own receptor on a cell is even more provocative because it might change the way we think about (Kaposi's sarcoma herpes virus-associated) diseases and their treatment."

The research appears in the journal Science.

Copyright 2006 by United Press International

Explore further: Longevity of AIDS patients presents new risks: US

Related Stories

Longevity of AIDS patients presents new risks: US

June 2, 2011

Thirty years after the AIDS epidemic first surfaced, more people than ever before in the United States -- more than 1.1 million -- are living with HIV, the Centers for Disease Control said Thursday.

Researchers identify new drug target for Kaposi's sarcoma

July 30, 2009

UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi's sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family ...

Using viruses to find the cellular Achilles heel

January 22, 2015

Back-to-back studies from researchers at the Gladstone Institutes have exposed new battle tactics employed by two deadly viruses: hepatitis C (HCV) and the Kaposi's sarcoma-associated herpesvirus (KSHV). Published in the ...

Detecting disease with a smartphone accessory

June 4, 2013

As antiretroviral drugs that treat HIV have become more commonplace, the incidence of Kaposi's sarcoma, a type of cancer linked to AIDS, has decreased in the United States. The disease, however, remains prevalent in sub-Saharan ...

Recommended for you

Which insects are the best pollinators?

September 3, 2015

Bees top the charts for pollination success according to one of the first studies of insect functionality within pollination networks, published today by researchers at the University of Bristol and the University of St Andrews.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.