New light on muscle efficiency: it is not the power-plant

March 22, 2006

A recent study from Scandinavia shows that the well-known differences between individuals in the efficiency of converting energy stored in food to work done by muscles are related to muscle fibre type composition and to the content of specific molecules in muscle.

When muscles contract they use energy that is derived from food. It is a two-step process. The first step occurs in mitochondria, where the energy from molecules like glucose or fats is locked away in ATP (adenosine triphosphate). This ATP travels from the mitochondria to sites in the muscle where energy is needed, and the energy is released and used. At both of these stages there is the possibility for energy to be lost, causing a reduction in efficiency. The proportion of food energy that ends up making the muscles move is a measure of the efficiency of the system, and this is known to vary considerably between people.

The main theory is that this variation comes from differences in the efficiency with which mitochondria convert food energy to ATP. But results published in this fortnight’s edition of The Journal of Physiology indicate that any differences in the efficiency of individual mitochondria cannot explain the differences in overall efficiency between people. Consequently these differences must lie in the way the ATP is used within the muscle.

The research was carried out on healthy human volunteers by a team of scientists working at the University of Southern Denmark, Odense, and the Karolinska Institute/GIH, in Stockholm, Sweden. It combined exercise testing of individuals, with laboratory analysis of muscle samples.

The results showed that work efficiency was correlated with muscle fibre type composition and with the amount of UCP3 protein – muscles with high proportions of this protein had lower efficiencies than those with low proportions.

“It’s too early to say whether UCP3 causes this difference, or whether it is a marker of some other process, but further research might someday lead to training strategies that will help us improve efficiency, or identify subjects who have the potential to become more efficient over time,” says lead author Martin Mogensen.

“The work is an excellent example of integrative physiology, addressing questions both at the sub-cellular and whole body levels that have implications for basic muscle energetics as well as athletic performance,” says Professor Edward Coyle, of the University of Texas at Austin, in an accompanying editorial.

Source: Blackwell Publishing Ltd.

Explore further: Muscles have circadian clocks that control exercise response

Related Stories

Basic structure of ultrasound power supply and communication

October 4, 2016

Unlike drugs, active implants such as electroceuticals act locally, have fewer side effects and function directly through electrical signals, much like the body itself. At the Medica 2016 trade fair in Düsseldorf, Fraunhofer ...

Sustainable sensors to detect, predict muscle fatigue

July 28, 2016

It may be clammy and inconvenient, but human sweat has at least one positive characteristic - it can give insight to what's happening inside your body. A new study published in the ECS Journal of Solid State Science and Technology ...

Motorized prosthetics improves lives of amputees

August 12, 2016

When asked about her chosen field, Deanna Gates, director of the Rehabilitation Biomechanics Laboratory at the University of Michigan, always joked that she wanted to make Luke Skywalker's hand.

Recommended for you

Shocks in the early universe could be detectable today

October 27, 2016

(—Physicists have discovered a surprising consequence of a widely supported model of the early universe: according to the model, tiny cosmological perturbations produced shocks in the radiation fluid just a fraction ...

Bubble nucleus discovered

October 27, 2016

Research conducted at the National Superconducting Cyclotron Laboratory at Michigan State University has shed new light on the structure of the nucleus, that tiny congregation of protons and neutrons found at the core of ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.