Yale scientists map cell signaling network

Nov 30, 2005

Yale University scientists have mapped, for the first time, the proteins and kinase signaling network that control how cells of higher organisms operate.

The researchers said their study is a breakthrough in understanding how proteins operate in different cell types under the control of master regulator molecules called protein kinases.

Although protein kinases are already important targets of cancer drugs, until recently it has been difficult to identify the proteins regulated by the kinases.

Led by Michael Snyder, a professor of molecular, cellular and developmental biology, the researchers focused on the expression and relationship between proteins of the yeast cell "proteome," or the proteins that are active in a cell.

Protein kinases act as regulator switches and modify their target proteins by adding a phosphate group to them. The process, called "phosphorylation," results in altered activity of the phosphorylated protein. It is estimated 30 percent of all proteins are regulated by that process.

The research is explained in this week's issue of the journal Nature.

Copyright 2005 by United Press International

Explore further: John Nash, wife, 'A Beautiful Mind' inspiration, die in NJ

Related Stories

Chameleon proteins make individual cells visible

May 19, 2015

Researchers discovered a new mechanism of how fluorescent proteins can change colour. It enables the microscopic visualization of individual cells in their three-dimensional environment in living organisms.

Power to the batteries

May 22, 2015

Better solar panels and wind turbines are important to helping ensure a low-carbon future. But they are not enough. The energy from these intermittent sources must be stored, managed, converted and accessed ...

Herpes virus hijackers

May 22, 2015

The virus responsible for the common cold sore hijacks the machinery within our cells, causing them to break down and help shield the virus from our immune system, researchers from the University of Cambridge ...

Recommended for you

Top UK scientists warn against EU exit

May 22, 2015

A group of leading British scientists including Nobel-winning geneticist Paul Nurse warned leaving the European Union could threaten research funding, in a letter published in The Times newspaper on Friday.

How we discovered the three revolutions of American pop

May 22, 2015

Dr Matthias Mauch discusses his recent scientific analysis of the "fossil record" of the Billboard charts prompted widespread attention, particularly the findings about the three musical "revolutions" that shaped the musical la ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.