Scientists find cancer cell defense method

Oct 05, 2005

A Seoul, South Korea, research team says it's identified the defense mechanism used by cancer cells to fight therapeutic chemicals.

Team leader Kim Kun-hong of Yonsei University told the Korea Times the discovery that enzyme protein kinase CK2 makes cancer cells resistant to cancer-specific therapeutic chemicals, such as "Trail," is a step toward developing effective treatments for the disease.

Kim said the enzyme influences a protein called procaspase-2 to become phosphate, which keeps the cells from dying and makes them resistant to medication.

However, when Trail was injected in the cancer cells with certain chemical substances the cells became sensitive to Trail and entered the normal death-inducing process.

The researchers tested 31 types of cancer cells and found that by suppressing PKCK2, Trail successfully killed the cancer cells in all the 31 types, regardless of the developmental stage of the cancer cell, Kim told the Korea Times.

The research appears in the online edition of the journal of the European Molecular Biology Organization.

Copyright 2005 by United Press International

Explore further: Scholar's new book explores fierce debates over immigration

Related Stories

How cells know which way to go

Oct 27, 2014

Amoebas aren't the only cells that crawl: Movement is crucial to development, wound healing and immune response in animals, not to mention cancer metastasis. In two new studies from Johns Hopkins, researchers ...

Chemists discover structure of cancer drug candidate

May 19, 2014

Chemists at The Scripps Research Institute (TSRI) have determined the correct structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials ...

Recommended for you

Challenges medical relief teams face after disaster

3 hours ago

As medical relief teams from Nepal and the rest of the world work to distribute supplies and care for survivors, it's worth understanding how health workers handle extreme emergency situations.

Dinosaur-times cockroach caught in amber, from Myanmar

May 01, 2015

Geologica Carpathica has a paper on a new family of predatory cockroaches. Predatory? The authors, Peter Vrsansky and Günter Bechly, from the Slovak Republic and Germany, respectively, said that "unique adapta ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.