PLoS Computational Biology is a peer-reviewed computational biology journal established in 2005 and published by the nonprofit Public Library of Science in association with the International Society for Computational Biology. Its Editor in Chief is Philip Bourne. All articles are open access and licensed under the Creative Commons Attribution License. The journal is well-known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. Due to their free licensing, files from PLoS Computational Biology can be reused in places other than the journal s website, e.g. to illustrate Wikipedia articles.
Deciphering the language of transcription factors
Transcription factors are proteins that bind to DNA to promote or suppress protein production. Since almost all diseases involve disruption of the protein-production process, transcription factors are promising biological ...
Researchers use computer model to probe mysteries of human immune system
A new computational model developed by a team of Virginia Tech researchers and published in PLoS Computational Biology provides a framework to better understand responses of macrophage cells of the human immune system.
The magic of the movies - molecules in 4D
(Phys.org) -- Computer simulations of how the body's tiniest building blocks behave are helping scientists to unlock the role of molecules in human diseases.
Bacteria branch out
(Phys.org) -- Streptomyces produce the majority of clinically useful antibiotics, yet we dont fully understand how they grow. PhD student Antje Hempel has contributed to our understanding of this by working out how ...
Finding the roots and early branches of the tree of life
A study published in PLoS Computational Biology maps the development of life-sustaining chemistry to the history of early life. Researchers Rogier Braakman and Eric Smith of the Santa Fe Institute traced the six methods of ...
Genome-scale model of cyanobacterium developed
(Phys.org) -- In an important step toward engineering bacteria to produce biofuel, scientists have developed one of the first global models for the nitrogen-fixing photosynthetic cyanobacterium Cyanothece sp. ATCC 51142 (see ...
Researchers examine mechanical bases for the emergence of undulatory swimmers
How do fish swim? It is a simple question, but there is no simple answer.
Computer simulations reveal the energy landscape of ion channels
Every cell of our body is separated from its environment by a lipid bilayer. In order to maintain their biological function and to transduce signals, special proteins, so called ion channels, are embedded in the membrane. ...
Early infant growth rate linked to composition of gut microbiota
The composition of gut microbiota in a new-born baby's gut has been linked to the rate of early infant growth, reports research published this week in PLOS Computational Biology. The findings support the assertion that the ...
DNA: How to unravel the tangle
A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundle's function.