PLoS Computational Biology is a peer-reviewed computational biology journal established in 2005 and published by the nonprofit Public Library of Science in association with the International Society for Computational Biology. Its Editor in Chief is Philip Bourne. All articles are open access and licensed under the Creative Commons Attribution License. The journal is well-known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. Due to their free licensing, files from PLoS Computational Biology can be reused in places other than the journal s website, e.g. to illustrate Wikipedia articles.
Simulating in tiny steps gave birth to long-sought-after method
Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. ...
Birds display lateralization bias when selecting flight paths
Flocks of birds manage to navigate through difficult environments by individuals having predispositions to favour the left- or right-hand side, according to research published in PLOS Computational Biology this week.
Randomness forms complex social structures
(Phys.org)—The environment of group-living animals influences their social behaviour in a stronger way than was previously thought, says a new study from behavioural researchers at ETH and the University of Zurich. They ...
Solving 1960s genetics mystery could clear obstacles for synthetic biologists
The threads of an evolutionary mystery that dates to the birth of molecular biology are beginning to unravel, thanks to a new investigation by computational bioengineers at Rice University and the University of Texas MD Anderson ...
Predatory bacterial crowdsourcing
(Phys.org)—Move forward. High-five your neighbor. Turn around. Repeat.
Deciphering the language of transcription factors
Transcription factors are proteins that bind to DNA to promote or suppress protein production. Since almost all diseases involve disruption of the protein-production process, transcription factors are promising biological ...
Researchers use computer model to probe mysteries of human immune system
A new computational model developed by a team of Virginia Tech researchers and published in PLoS Computational Biology provides a framework to better understand responses of macrophage cells of the human immune system.
The magic of the movies - molecules in 4D
(Phys.org) -- Computer simulations of how the body's tiniest building blocks behave are helping scientists to unlock the role of molecules in human diseases.
Bacteria branch out
(Phys.org) -- Streptomyces produce the majority of clinically useful antibiotics, yet we dont fully understand how they grow. PhD student Antje Hempel has contributed to our understanding of this by working out how ...
Finding the roots and early branches of the tree of life
A study published in PLoS Computational Biology maps the development of life-sustaining chemistry to the history of early life. Researchers Rogier Braakman and Eric Smith of the Santa Fe Institute traced the six methods of ...