PLoS Computational Biology is a peer-reviewed computational biology journal established in 2005 and published by the nonprofit Public Library of Science in association with the International Society for Computational Biology. Its Editor in Chief is Philip Bourne. All articles are open access and licensed under the Creative Commons Attribution License. The journal is well-known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. Due to their free licensing, files from PLoS Computational Biology can be reused in places other than the journal s website, e.g. to illustrate Wikipedia articles.
Geometry, programmed death might have enabled evolution of multicellularity
Geometry and programmed cell death may have helped along the evolution of multicellular life, according to new research led by SFI Omidyar Fellow Eric Libby.
Computer simulations visualize ion flux
Ion channels are involved in many physiological and pathophysiological processes throughout the human body. A young team of researchers led by pharmacologist Anna Stary-Weinzinger from the Department of Pharmacology ...
Should we listen to our genes, or does mother know best?
Breaking the mould of inherited family characteristics could help you survive in a fast-changing world, scientists have discovered.
Simulating in tiny steps gave birth to long-sought-after method
Using computer simulations to predict which drug candidates offer the greatest potential has thus far not been very reliable, because both small drug-like molecules and the amino acids of proteins vary so much in their chemistry. ...
Birds display lateralization bias when selecting flight paths
Flocks of birds manage to navigate through difficult environments by individuals having predispositions to favour the left- or right-hand side, according to research published in PLOS Computational Biology this week.
Can walkies tell who's the leader of the pack?
Dogs' paths during group walks could be used to determine leadership roles and through that their social ranks and personality traits, say researchers from Oxford University, Eötvös University, Budapest ...
Environment affects an organism's complexity
Scientists have demonstrated that organisms with greater complexity are more likely to evolve in complex environments, according to research published this week in PLOS Computational Biology. The researchers, based at Éc ...
Scientists explore the mechanisms of viruses' shells
The genome of viruses is usually enclosed inside a shell called capsid. Capsids have unique mechanic properties: they have to be resistant and at the same time capable of dissolving in order to release the ...
Study analyzes dynamical properties in antibiotic resistance enzyme
Antibiotic-resistant bacteria have been emerging at an alarming rate. In some of the scariest of these pathogens, the mechanism responsible for the bacteria's ability to defeat antibiotics is a complex protein ...
Researchers examine mechanical bases for the emergence of undulatory swimmers
How do fish swim? It is a simple question, but there is no simple answer.
Researchers conclude that what causes menopause is—wait for it—men
After decades of laboring under other theories that never seemed to add up, a team led by biologist Rama Singh has concluded that what causes menopause in women is men.
New study proposes solution to long-running debate as to how stable the Earth system is
Researchers at the University of Southampton have proposed an answer to the long-running debate as to how stable the Earth system is.
Early infant growth rate linked to composition of gut microbiota
The composition of gut microbiota in a new-born baby's gut has been linked to the rate of early infant growth, reports research published this week in PLOS Computational Biology. The findings support the assertion that t ...
Computer simulations reveal the energy landscape of ion channels
Every cell of our body is separated from its environment by a lipid bilayer. In order to maintain their biological function and to transduce signals, special proteins, so called ion channels, are embedded ...
DNA: How to unravel the tangle
A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundle's function.