PLoS Computational Biology is a peer-reviewed computational biology journal established in 2005 and published by the nonprofit Public Library of Science in association with the International Society for Computational Biology. Its Editor in Chief is Philip Bourne. All articles are open access and licensed under the Creative Commons Attribution License. The journal is well-known beyond its core field for its Ten Simple Rules series of articles that capture the essence of selected aspects of research in computational biology or in science more generally, e.g. how to present a poster, how to collaborate, or how to edit Wikipedia. Due to their free licensing, files from PLoS Computational Biology can be reused in places other than the journal s website, e.g. to illustrate Wikipedia articles.
Study analyzes dynamical properties in antibiotic resistance enzyme
Antibiotic-resistant bacteria have been emerging at an alarming rate. In some of the scariest of these pathogens, the mechanism responsible for the bacteria's ability to defeat antibiotics is a complex protein ...
Researchers examine mechanical bases for the emergence of undulatory swimmers
How do fish swim? It is a simple question, but there is no simple answer.
Researchers conclude that what causes menopause is—wait for it—men
After decades of laboring under other theories that never seemed to add up, a team led by biologist Rama Singh has concluded that what causes menopause in women is men.
New study proposes solution to long-running debate as to how stable the Earth system is
Researchers at the University of Southampton have proposed an answer to the long-running debate as to how stable the Earth system is.
Early infant growth rate linked to composition of gut microbiota
The composition of gut microbiota in a new-born baby's gut has been linked to the rate of early infant growth, reports research published this week in PLOS Computational Biology. The findings support the assertion that t ...
Computer simulations reveal the energy landscape of ion channels
Every cell of our body is separated from its environment by a lipid bilayer. In order to maintain their biological function and to transduce signals, special proteins, so called ion channels, are embedded ...
DNA: How to unravel the tangle
A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundle's function.
Robot ants successfully mimic real colony behavior
Scientists have successfully replicated the behaviour of a colony of ants on the move with the use of miniature robots, as reported in the journal PLOS Computational Biology.
Under the hood of the ribosome
(Phys.org) —We all know—generally speaking—how a car works: The gas pedal makes it go, the break pedal makes it stop, and the steering wheel determines its course. But pop open the hood and you'll find ...
Computer simulations yield clues to how cells interact with surroundings
(Phys.org) —Your cells are social butterflies. They constantly interact with their surroundings, taking in cues on when to divide and where to anchor themselves, among other critical tasks.
Too small and numerous to count: Better ways to estimate the diversity of unseen life on and in our bodies
(Phys.org)—Ecologists often rely on the twin standards of the variety and numbers of species to describe a given region's diversity. But scaling down the size also scales up the numbers: On and in our bodies is a community ...
Target 'super-spreaders' to stop hepatitis C
Each intravenous drug user contracting Hepatitis C is likely to infect around 20 other people with the virus, half of these transmissions occurring in the first two years after the user is first infected, a new study estimates.
Protein origami: Quick folders are the best
The evolutionary history of proteins shows that protein folding is an important factor. Especially the speed of protein folding plays a key role. This was the result of a computer analysis carried out by ...
Was life inevitable? New paper pieces together metabolism's beginnings
(Phys.org)—Describing how living organisms emerged from Earth's abiotic chemistry has remained a conundrum for scientists, in part because any credible explanation for such a complex process must draw from fields spanning ...
Researcher looks to whirligig beetle for bio-inspired robots
Whirligig beetles are named for their whirling movement on top of water, moving rapidly in and taking off into flight.