Nucleic Acids Research is a peer-reviewed scientific journal published by Oxford University Press. It covers research on nucleic acids, such as DNA and RNA, and related work. Some of its content is available under an open access license. According to the Journal Citation Reports, the journal s 2010 impact factor is 7.836. The journal publishes two yearly special issues, one dedicated to biological databases, published in January since 1993 and the other on biological web servers, published in July since 2003.
Technique uses bacteria's own CRISPR-Cas system to turn off gene
Researchers from North Carolina State University have developed a technique that co-opts an immune system already present in bacteria and archaea to turn off specific genes or sets of genes – creating a ...
'Office life' of bacteria may be their weak spot
Scientists at the University of Leeds think we may be able to drown deadly bacteria in their own paperwork.
RNAcentral provides a single access point to non-coding RNA data
RNAcentral, the first unified resource for all types of non-coding RNA data, has been launched today by the RNAcentral Consortium. It aggregates information from a federation of expert databases, and provides tools for easy ...
To watch DNA unwrap, blank out the proteins
Biophysics is a science of shapes – the shapes of molecules like DNA as they wrap and unwrap around protein cores, for instance. Cornell researchers have unveiled a new method for observing such processes ...
Powerful tool for genetic engineering: Researchers describe new possibilities of the CRISPR-Cas-system
Viruses cannot only cause illnesses in humans, they also infect bacteria. Those protect themselves with a kind of 'immune system' which – simply put – consists of specific sequences in the genetic material ...
Scientists report breakthrough in DNA editing technology
Scientists at The Scripps Research Institute (TSRI) have found a way to apply a powerful new DNA-editing technology more broadly than ever before.
New insight into the human genome through the lens of evolution
By comparing the human genome to the genomes of 34 other mammals, Australian scientists have described an unexpectedly high proportion of functional elements conserved through evolution.
1-D to 3-D genomics
(Phys.org) —Since his recent selection as an Alfred P. Sloan Research Fellow, Remo Rohs continues to demonstrate the research and creativity necessary to become a leader in the scientific community.
Research describes new techniques to study protein-DNA interactions
Work undertaken at the John Innes Centre describes new Surface Plasmon Resonance (SPR) protocols to identify and footprint protein-DNA interactions in a cost effective and semi-automated way.
Predictability: The brass ring for synthetic biology
(Phys.org) —Predictability is often used synonymously with "boring," as in that story or that outcome was soooo predictable. For practitioners of synthetic biology seeking to engineer valuable new microbes, ...
Protein abundant in cancerous cells causes DNA 'supercoiling'
A team of USC scientists has identified a protein that can change DNA topology, making DNA twist up into a so-called "supercoil."
How a microbial biorefinery regulates genes
Microorganisms that can break down plant biomass into the precursors of biodiesel or other commodity chemicals might one day be used to produce alternatives to petroleum. But the potential of this "biorefinery" ...
Discovery in synthetic biology takes us a step closer to new 'industrial revolution'
Scientists report that they have developed a method that cuts down the time it takes to make new 'parts' for microscopic biological factories from two days to only six hours.
Researchers study the structure of drug resistance in tuberculosis
(Phys.org) -- Edward Yu took note of the facts – nearly 2 million deaths each year, 9 million infected each year, developments of multidrug-resistant, extensively drug-resistant and now totally drug-resistant ...
Viruses with integrated gene switch
Scientists of the German Cancer Research Center have developed "RNA switches" which allow them to specifically turn on and off genes in viruses. This will help to enhance regulation of gene therapy and viral therapy of cancer.