Nature Methods

Single cells seen in unprecedented detail

Researchers have developed a large-scale sequencing technique called Genome and Transcriptome Sequencing (G&T-seq) that reveals, simultaneously, the unique genome sequence of a single cell and the activity of genes within ...

dateApr 27, 2015 in Biotechnology
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Decoding the cell's genetic filing system

A fully extended strand of human DNA measures about five feet in length. Yet it occupies a space just one-tenth of a cell by wrapping itself around histones—spool-like proteins—to form a dense hub of information called ...

dateApr 22, 2015 in Biochemistry
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Unidentified spectra detector

A new algorithm clusters the millions of peptide mass spectra in the PRIDE Archive public database, making it easier to detect millions of consistently unidentified spectra across different datasets. Published in Nature Methods, ...

dateJun 28, 2016 in Mathematics
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A guide to CRISPR gene activation

The CRISPR-Cas9 system has come to be known as the quintessential tool that allows researchers to edit the DNA sequences of many organisms and cell types. However, scientists are also increasingly recognizing that it can ...

dateMay 23, 2016 in Biotechnology
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