Nature Methods

Single cells seen in unprecedented detail

Researchers have developed a large-scale sequencing technique called Genome and Transcriptome Sequencing (G&T-seq) that reveals, simultaneously, the unique genome sequence of a single cell and the activity ...

date2 hours ago in Biotechnology
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Decoding the cell's genetic filing system

A fully extended strand of human DNA measures about five feet in length. Yet it occupies a space just one-tenth of a cell by wrapping itself around histones—spool-like proteins—to form a dense hub of ...

dateApr 22, 2015 in Biochemistry
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Activating genes on demand

When it comes to gene expression - the process by which our DNA provides the recipe used to direct the synthesis of proteins and other molecules that we need for development and survival - scientists have ...

dateMar 04, 2015 in Biotechnology
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End of CRISPR-CAS9 controversy

The IBS research team (Center for Genome Engineering) has successfully confirmed that CRISPR-Cas9 has accurate on-target effects in human cells, through joint research with the Seoul National University College ...

dateFeb 10, 2015 in Cell & Microbiology
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First sensor for 'crowd control' in cells

University of Groningen scientists have developed a molecular sensor to measure 'crowding' in cells, which reflects the concentration of macromolecules present. The sensor provides quantitative information ...

dateFeb 02, 2015 in Biochemistry
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