The Journal of Medicinal Chemistry (usually abbreviated as J. Med. Chem.), is a peer-reviewed scientific journal, published since 1959 by the American Chemical Society. It was originally published as the Journal of Medicinal and Pharmaceutical Chemistry, but changed its name in 1963 to the current title. Profs. Gunda I. Georg of the University of Minnesota and Shaomeng Wang of the University of Michigan are the Editors of the journal. They took over leadership from Prof. Philip S. Portoghese of the University of Minnesota in 2012. Prof. Portoghese had served as Editor in Chief from 1972 - 2011. The Journal of Medicinal Chemistry publishes original research on the correlation of molecular structure to biological activity with a focus on the relationships of chemistry to biological activity.
Recent research has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.
Analytical Chemistry
Jan 19, 2024
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A study published in the Journal of Medicinal Chemistry reports the discovery of a novel PHD inhibitor for the treatment of anemia.
Analytical Chemistry
Jan 19, 2024
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Prof. Bernd Plietker and his research group at the Chair of Organic Chemistry I at TUD have specifically developed a class of natural substances—polyprenylated polycyclic acylphloroglucinols (PPAP for short). Due to its ...
Biochemistry
Dec 11, 2023
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A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like ...
Biochemistry
Nov 8, 2023
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According to the Centers for Disease Control, 100,000 Americans die each year from an overdose, most due to the use of synthetic opiates like fentanyl. While naloxone, currently the only an antidote for opiate overdose, has ...
Biochemistry
Jul 18, 2023
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Scientists at The Institute of Cancer Research, London, have created a compound that destroys a protein involved in driving cancers, including B-cell lymphoma.
Biochemistry
Apr 26, 2023
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There is a need for new drugs. For example, many of the antibiotics that we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active substances, ...
Biochemistry
Apr 13, 2023
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Surprisingly, bitter taste receptors are not only located in the mouth, but also elsewhere in the body, including the airways. Activating those receptors opens up lung passageways, so they're a potential target for treating ...
Biochemistry
Mar 13, 2023
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Researchers from the Institute for Advanced Chemistry of Catalonia (IQAC) of Spanish National Research Council (CSIC) have developed a series of photosensitive molecule drugs that can be reversibly activated by external light, ...
Biochemistry
Feb 16, 2023
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60
Chemotherapy sucks. The treatments generally have awful side effects, and it's no secret that the drugs involved are often toxic to the patient as well as their cancer. The idea is that, since cancers grow so quickly, chemotherapy ...
Biochemistry
Aug 24, 2022
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