Genome Biology

Genomics is a discipline in genetics concerned with the study of the genomes of organisms. The field includes efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome s networks. For the United States Environmental Protection Agency, "the term "genomics" encompasses a broader scope of scientific inquiry associated technologies than when genomics was initially considered. A genome is the sum total of all an individual organism s genes. Thus, genomics is the study of all the genes of a cell, or tissue, at the DNA (genotype), mRNA (transcriptome), or protein (proteome) levels." The

Publisher
BioMed Central
Country
United Kingdom
History
2000–present
Impact factor
6.89 (2011)
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Finding meaning in gene expression 'noise'

Static models of gene regulation networks are inevitably oversimplified, indicating how one gene specifically switches certain target genes on while turning others off. However, the reality is much more dynamic and thus noisier. ...

dateJan 10, 2014 in Biotechnology
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Honey bees fight back against Varroa

The parasitic mite Varroa destructor is a major contributor to the recent mysterious death of honey bee (Apis mellifera) colonies. New research published in BioMed Central's open access journal Genome Biology finds that specific ...

dateSep 27, 2012 in Plants & Animals
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Very berry study aims to improve wine quality

A gene expression study of grapevine berries grown in different Italian vineyards has highlighted genes that help buffer the plants against environmental change and may explain the different quality performances of grapevine ...

dateJun 06, 2013 in Biotechnology
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