ChemMedChem is a monthly peer-reviewed medicinal chemistry journal. It is co-owned by the 14 European chemical society members of ChemPubSoc Europe and is published by Wiley-VCH. Its 2010 impact factor is 3.306. In addition to original research in the form of full papers and shorter communications, ChemMedChem contains review-type articles (reviews, minireviews, essays, highlights) as well as occasional book reviews and conference reports. The first volume was published at the beginning of 2006 under the two founding chemical societies, the German Chemical Society (GDCh) and the Italian Chemical Society (SCI). Since then, 12 additional chemical societies have joined in co-ownership of the journal. ChemMedChem is a sister publication to other scientific journals published by Wiley-VCH, including Angewandte Chemie, ChemBioChem, ChemPhysChem, ChemSusChem, and ChemCatChem. Topics covered in ChemMedChem include drug design, development and delivery, molecular modeling, combinatorial chemistry, drug target validation, lead generation, and ADMET studies.
An experimental drug that attacks brain tumor tissue by crippling the cells' energy source called the mitochondria has passed early tests in animal models and human tissue cultures, say Houston Methodist scientists.
Biochemistry
Mar 24, 2015
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A tsetse fly bites a girl. She becomes itchy, feverish, and her joints ache. Weeks later, she loses coordination and some sensation in her limbs. It becomes difficult to think, to sleep.
Biochemistry
Oct 6, 2014
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Thrombin plays a key role in various pathologies of the haemostatic system. Overexpression of thrombin can result in thrombosis, whereas its underexpression might lead to haemophilia. Therefore, accurate monitoring of thrombin ...
Biochemistry
Feb 23, 2012
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(Phys.org)—Iodide entrapment in the thyroid gland is essential, and plays a key role in dysfunctions such as thyroid and breast cancers, thyroiditis, Graves–Basedow disease, and Hashimoto's disease. The accidents at Chernobyl ...
Biochemistry
Nov 8, 2012
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Molecules that bind and illuminate proteins specific to tumor cells are key to detecting cancer as early as possible. The cyclooxygenase-2 (COX-2) enzyme is just such a protein, as the concentration of COX-2 is greater in ...
Biochemistry
Nov 7, 2013
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(Phys.org) -- New drug candidates require testing in animal models prior to approval for clinical use. A recently developed antagonist based on a bicyclic peptide inhibited the human serine protease plasma kallikrein potently ...
Biochemistry
Apr 13, 2012
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A team of interdisciplinary researchers from the Institut National de la Recherche Scientifique (INRS) is hoping to identify effective COVID-19 therapeutics. With help from the Canadian Light Source (CLS) at the University ...
Biochemistry
Sep 28, 2022
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While the first vaccines have been developed against the pathogen SARS-CoV-2, studies are still underway to identify effective drugs for treating coronavirus infections. Scientists in Gießen, Mainz, and Würzburg in Germany ...
Molecular & Computational biology
Jan 18, 2021
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Researchers at the University of Eastern Finland have developed novel antibacterial compounds, focusing on the role of LsrK kinase. LsrK kinase is a protein involved in bacterial communication. In a new study published in ...
Biochemistry
Nov 1, 2018
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A group of biologists, theoretical chemists and synthetic chemists at ITbM have come together to develop a small molecule that slows down the circadian clock rhythm through binding to the CRY clock protein.
Biochemistry
Feb 8, 2016
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