Chemistry & Biology publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.
Team finds a better way to engineer therapeutic proteins into antibodies
Some proteins exist so fleetingly in the bloodstream that they can't be given effectively as therapies. However, building them into larger proteins, such as antibodies, can make them persist long enough to be useful. Now ...
New approach holds promise for earlier, easier detection of colorectal cancer
Chemists at Caltech have developed a new sensitive technique capable of detecting colorectal cancer in tissue samples—a method that could one day be used in clinical settings for the early diagnosis of colorectal cancer.
Sunflower protein 'scissors' provide sunny news for medicine
Scientists have discovered an extraordinary protein-cutting enzyme that has also evolved to glue proteins together, a finding that may be valuable in the production of therapeutic drugs.
Targeting one enzyme is the key to tackling two tropical diseases
A way to combat malaria developed by scientists at Imperial College London and the University of York may also be effective against the deadly tropical disease leishmaniasis, new research has shown.
A poisonous cure
Take two poisonous mushrooms, and call me in the morning. While no doctor would ever write this prescription, toxic fungi may hold the secrets to tackling deadly diseases.
New studies bring scientists closer to combating dangerous unstable proteins
Scientists at The Scripps Research Institute (TSRI) have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases.
Promising drug candidate protects against radiation exposure from nuclear fallout
The 2011 Fukushima disaster was a stark reminder of the continuing dangers posed by nuclear fallout, highlighting the need for an approved drug that can be taken after radiation exposure to protect against organ injury and ...
Researchers study vital 'on/off switches' that control when bacteria turn deadly
(Phys.org) —No matter how many times it's demonstrated, it's still hard to envision bacteria as social, communicating creatures. But by using a signaling system called "quorum sensing," these single-celled organisms radically ...
Preventing cell death from infection: Scientists demonstrate method to find new therapies
Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find—relatively quickly and cheaply—antibodies that have a desired effect on cells. ...
Team charts new understanding of actin filament growth in cells
University of Oregon biochemists have determined how tiny synthetic molecules disrupt an important actin-related molecular machine in cells in one study and, in a second one, the crystal structure of that machine when bound ...