Chemistry & Biology publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.
Sunflower protein 'scissors' provide sunny news for medicine
Scientists have discovered an extraordinary protein-cutting enzyme that has also evolved to glue proteins together, a finding that may be valuable in the production of therapeutic drugs.
Targeting one enzyme is the key to tackling two tropical diseases
A way to combat malaria developed by scientists at Imperial College London and the University of York may also be effective against the deadly tropical disease leishmaniasis, new research has shown.
Promising drug candidate protects against radiation exposure from nuclear fallout
The 2011 Fukushima disaster was a stark reminder of the continuing dangers posed by nuclear fallout, highlighting the need for an approved drug that can be taken after radiation exposure to protect against organ injury and ...
A poisonous cure
Take two poisonous mushrooms, and call me in the morning. While no doctor would ever write this prescription, toxic fungi may hold the secrets to tackling deadly diseases.
New studies bring scientists closer to combating dangerous unstable proteins
Scientists at The Scripps Research Institute (TSRI) have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases.
Researchers study vital 'on/off switches' that control when bacteria turn deadly
(Phys.org) —No matter how many times it's demonstrated, it's still hard to envision bacteria as social, communicating creatures. But by using a signaling system called "quorum sensing," these single-celled organisms radically ...
New technology may help identify safe alternatives to BPA
Numerous studies have linked exposure to bisphenol A (BPA) in plastic, receipt paper, toys, and other products with various health problems from poor growth to cancer, and the FDA has been supporting efforts ...
New technology using florescent proteins tracks cancer cells circulating in the blood
After cancer spreads, finding and destroying malignant cells that circulate in the body is usually critical to patient survival. Now, researchers reporting in the Cell Press journal Chemistry & Biology have d ...
Large-scale identification and analysis of suppressive drug interactions
Baker's yeast is giving scientists a better understanding of drug interactions, which are a major cause of hospitalization and illness world-wide.
Enzyme 'wrench' could be key to stronger, more effective antibiotics
Builders and factory workers know that getting a job done right requires precision and specialized tools. The same is true when you're building antibiotic compounds at the molecular level. New findings from North Carolina ...
Commonly used pain relievers have added benefit of fighting bacterial infection
Some commonly used drugs that combat aches and pains, fever, and inflammation are also thought to have the ability to kill bacteria. New research appearing online on March 13 in the Cell Press journal Chemistry & ...
Scientists find resistance mechanism that could impact antibiotic drug development
The use of antibiotics is often considered among the most important advances in the treatment of human disease. Unfortunately, though, bacteria are finding ways to make a comeback. According to the Centers ...
Preventing cell death from infection: Scientists demonstrate method to find new therapies
Scientists at The Scripps Research Institute (TSRI) have demonstrated the power of a new drug discovery technique, which allows them to find—relatively quickly and cheaply—antibodies that have a desired ...
New substance effectively combats multi-resistant bacteria
In Europe alone, more than 25,000 people die each year from infections caused by multi-resistant bacteria. Researchers from University of Copenhagen have now developed and characterized a substance that quickly and effectively ...
A new way to fight antibiotic-resistant bacteria
At a time when scientists are quickly running out of options, McMaster researchers are using a new approach to fighting antibiotic-resistant bacteria.