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Adult cells transformed into early-stage nerve cells, bypassing the pluripotent stem cell stage
A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells—without passing through the do-it-all stage called the induced ...
May 02, 2013
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Researchers 'capture' the replication of the human genome for the first time
The Genomic Instability Group led by researcher Óscar Fernández-Capetillo at the Spanish National Cancer Research Centre (CNIO), has for the first time obtained a panoramic photo of the proteins that take part in human ...
Apr 25, 2013
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Healing by the clock: In fruit flies, intestinal stem-cell regeneration fluctuates with the time of day
Circadian rhythms keep time for all living things, from regulating when plants open their flowers to foiling people when they try to beat jet lag. Day-night cycles are controlled through ancient biological ...
Apr 11, 2013
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Dual systems key to keeping chromosomes intact
USC scientists have discovered how two different structural apparatuses collaborate to protect repetitive DNA when it is at its most vulnerable – while it is being unzipped for replication.
Mar 07, 2013
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Putting malaria on the SHELPH
Experts have disabled a unique member of the signalling proteins which are essential for the development of the malaria parasite. They have produced a mutant lacking the ancient bacterial Shewanella-like protein phosphatase ...
Feb 25, 2013
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Scientists develop mouse model that can advance research on iPS cells to the next step
VIB scientists associated to the UGent have developed a mouse model that can advance the research on iPS cells to the next step.
Feb 21, 2013
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Key protein revealed as trigger for stem cell development
A natural trigger that enables stem cells to become any cell-type in the body has been discovered by scientists.
Feb 07, 2013
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Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene
Somites, precursors for the segmental structures such as the vertebral column, ribs and skeletal muscles, form periodically by segmentation of the rostral parts of the presomitic mesoderm (PSM). This periodic ...
Jan 09, 2013
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In epigenomics, location is everything: Researchers exploit gene position to test 'histone code'
In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome – and ...
Jan 03, 2013
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New study finds that one key mechanism in development involves 'paused' RNA polymerase
For a tiny embryo to grow into an entire fruit fly, mouse or human, the correct genes in each cell must turn on and off in precisely the right sequence. This intricate molecular dance produces the many parts of the whole ...
Dec 20, 2012
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Stem cells develop best in 3-D
Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells. In the long term this new knowledge ...
Nov 21, 2012
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Identification of gene that promotes differentiation of pluripotential cells through analysis of classical mouse mutant
Researchers at RIKEN BioResource Center and their colleagues identified a gene required for growth and differentiation of pluripotential cells in the mouse embryos. The gene, Vps52, is a mouse ...
Nov 09, 2012
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A secret of tumor stem cell survival: Scientists make progress against a devastating cancer
Malignant glioma is generally a death sentence for patients. These tumors, which arise from non-neuronal cells within the brain, grow quickly and aggressively, and contain a core population of glioma stem ...
Nov 07, 2012
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Researchers advance ability to control biological processes at cell-level
Researchers at Tokyo Institute of Technology and the Weizmann Institute of Science identify a means of controlling biological processes that could help treatments for immune disease, neurological disorders ...
Nov 01, 2012
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Genetic tradeoff: Harmful genes are widespread in yeast but hold hidden benefits
The genes responsible for inherited diseases are clearly bad for us, so why hasn't evolution, over time, weeded them out and eliminated them from the human genome altogether? Part of the reason seems to be that genes that ...
Oct 25, 2012
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