A new high-quality, open-access journal from Cell Press covering all of life science.
Scientists develop comparative search engine that helps to predict human gene function
The Human Genome Project wrapped up over a decade ago, yet around a third of the genome remains mysterious, its function unknown. Now, School of Medicine researchers have developed a comparative search engine ...
Microbes prevent malnutrition in fruit flies—and maybe humans, too
Microbes, small and ancient life forms, play a key role in maintaining life on Earth. As has often been pointed out, without microbes, we'd die—without us, most microbes would get along just fine.
How the Eastern tiger swallowtail got 'scary'
As butterflies go, the Eastern tiger swallowtail is pretty scary. Their caterpillars look more like stubby snakes, complete with a fake green head, faux black and yellow eyes, and an orange, forked, fleshy ...
Temperature dependence and the thermal limits of embryogenesis
Ancient 'genomic parasites' spurred evolution of pregnancy in mammals
An international team of scientists has identified large-scale genetic changes that marked the evolution of pregnancy in mammals.
Growing functioning brain tissue in 3D
Researchers at the RIKEN Center for Developmental Biology in Japan have succeeded in inducing human embryonic stem cells to self-organize into a three-dimensional structure similar to the cerebellum, providing ...
Understanding cellular ageing
Researchers at the BBSRC-supported Babraham Institute have mapped the physical structure of the nuclear landscape in unprecedented detail to understand changes in genomic interactions occurring in cell senescence ...
Cellular memory of stressful situations
Stress is unhealthy. The cells use therefore a variety of mechanisms to deal with stress and avert its immediate threat. However, certain stressful situations leave marks that go beyond the immediate response; ...
Twist1: Complex regulator of cell shape and function
Transcription factor Twist1 is involved in many processes where cells change shape or function. Thereby, Twist1 is crucial for embryonic development, but has also been implicated in cancer progression. However, the precise ...
Tumour-blocking role found for cell regulation molecule
Manchester scientists have explored the role of a protein in regulating tumour development and found that it suppresses liver cancer growth in the lab.
Scientists sequence genome of bowhead whale—longest-lived mammal
Scientists at the University of Liverpool have sequenced the genome of the bowhead whale, estimated to live for more than 200 years with low incidence of disease.
Locking mechanism found for 'scissors' that cut DNA
Researchers at Johns Hopkins have discovered what keeps an enzyme from becoming overzealous in its clipping of DNA. Since controlled clipping is required for the production of specialized immune system proteins, ...
Stem cells born out of indecision
Scientists at the University of Copenhagen have gained new insight into embryonic stem cells and how blocking their ability to make choices explains why they stay as stem cells in culture. The results have just been published ...
Surprise gene finding on "back or belly" decision in sea anemones
A gene that controls one of the earliest decisions in the life of an animal, where to place the back and the belly on the body, is identified in a sea anemone by researchers in Bergen, Norway.
A control knob for fat? Protein that makes other proteins also regulates fat levels
Like a smart sensor that adjusts the lighting in each room and a home's overall temperature, a protein that governs the making of other proteins in the cell also appears capable of controlling fat levels in the body.