A new high-quality, open-access journal from Cell Press covering all of life science.
Twist1: Complex regulator of cell shape and function
Transcription factor Twist1 is involved in many processes where cells change shape or function. Thereby, Twist1 is crucial for embryonic development, but has also been implicated in cancer progression. However, the precise ...
Tumour-blocking role found for cell regulation molecule
Manchester scientists have explored the role of a protein in regulating tumour development and found that it suppresses liver cancer growth in the lab.
Scientists sequence genome of bowhead whale—longest-lived mammal
Scientists at the University of Liverpool have sequenced the genome of the bowhead whale, estimated to live for more than 200 years with low incidence of disease.
Locking mechanism found for 'scissors' that cut DNA
Researchers at Johns Hopkins have discovered what keeps an enzyme from becoming overzealous in its clipping of DNA. Since controlled clipping is required for the production of specialized immune system proteins, ...
Stem cells born out of indecision
Scientists at the University of Copenhagen have gained new insight into embryonic stem cells and how blocking their ability to make choices explains why they stay as stem cells in culture. The results have just been published ...
Surprise gene finding on "back or belly" decision in sea anemones
A gene that controls one of the earliest decisions in the life of an animal, where to place the back and the belly on the body, is identified in a sea anemone by researchers in Bergen, Norway.
A control knob for fat? Protein that makes other proteins also regulates fat levels
Like a smart sensor that adjusts the lighting in each room and a home's overall temperature, a protein that governs the making of other proteins in the cell also appears capable of controlling fat levels in the body.
Protein kinase R and dsRNAs, new regulators of mammalian cell division
The research team of the Center for RNA Research at IBS has succeeded in revealing that the dsRNAs and Protein Kinase R (PKR) regulate division of mammalian cells.
Signaling molecule crucial to stem cell reprogramming
While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with ...
It's not always the DNA: Damaged messenger RNA can jam cellular machines that make protein
Damage to DNA is an issue for all cells, particularly in cancer, where the mechanisms that repair damage typically fail. The same agents that damage DNA also damage its sister molecule messenger RNA (mRNA), ...
Blocking a fork in the road to DNA replication
A team of Whitehead Institute scientists has discovered the surprising manner in which an enigmatic protein known as SUUR acts to control gene copy number during DNA replication. It's a finding that could shed new light on ...
A mechanism that allows a differentiated cell to reactivate as a stem cell revealed
The study, performed with fruit flies, describes a gene that determines whether a specialized cell conserves the capacity to become a stem cell again. Unveiling the genetic traits that favour the retention ...
How cells know which way to go
Amoebas aren't the only cells that crawl: Movement is crucial to development, wound healing and immune response in animals, not to mention cancer metastasis. In two new studies from Johns Hopkins, researchers ...
Shaking up cell biology: Researchers focus in on decades-old mitochondrial mystery
Elvis did it, Michael Jackson did it, and so do the mitochondria in our cells. They shake. While Elvis and Michael shook for decades before loud and appreciative audiences, mitochondrial oscillations have ...
Tick protein does the trick to fight infection
A protein in ticks that protects them against the cold could inspire a new class of antibiotics for humans, according to a Yale University study.