How new technologies will impact the engineering of biological systems
A new Biotechnology and Bioengineering viewpoint article provides insights on how rapid advancements in DNA reading and writing technologies will impact how researchers go about engineering biological systems, which include ...
Bacterial defense systems have numerous clinical and research applications
A new review highlights the diverse ways in which genetic-based defense systems found in bacteria can be harnessed to manipulate the microbes for various clinical and research applications. The systems, called CRISPR-Cas ...
Investigators insert large DNA sequence into mammalian cells
For the first time, researchers have used a simplified technique derived from a defense mechanism evolved by bacteria and other single-celled organisms to successfully insert a large DNA sequence into a predetermined genomic ...
Structure-based design used as tool for engineering deimmunized biotherapeutics
In the first experimental use of algorithms that employ structure-based molecular modeling to optimize deimmunized drug candidates, Karl Griswold, PhD, and co-investigator Christopher Bailey-Kellogg, PhD of Dartmouth College ...
Getting yeast to pump up the protein production
From manufacturing life-saving biopharmaceuticals to producing energy-efficient biofuels, the cost-effective production of proteins will be essential to revolutionizing the future of healthcare and energy.
New clinical platform may accelerate discovery of diagnostic and therapeutic agents
Researchers at University of British Columbia have developed a new technology that enables rapid discovery of aptamers, one of the fastest growing classes of diagnostic and therapeutic agents. Aptamers are short sequences ...
The future of 'bioprocessing' for medical therapies
What's in store for the future of industrial bioprocessing for medical therapies, which involves the use of living organisms or cells to create drugs or other agents? Will the batch or continuous bioprocessing platform dominate ...
Working together: Bacteria join forces to produce electricity
Bacterial cells use an impressive range of strategies to grow, develop and sustain themselves. Despite their tiny size, these specialized machines interact with one another in intricate ways.
Defining function from "genomic dark matter"
Functional annotation allowed researchers to identify biomass-degrading enzymes in the 35 percent of genes in a genome that are considered "genomic dark matter."
New screening technique paves the way for protein drugs from bacteria
A cheaper, more efficient technique for developing complex protein drugs from bacteria has been developed at the University of Sheffield.